Preprints

Watch this space for our new research!

Original investigations

Morais-Silva G, Campbell R, Nam H, Basu M, Pagliusi MO, Fox ME, Chan CS, Iñiguez SD, Ament S, Cramer N, Marin MT, Lobo MK, (2021). Activation of Npas1 neurons in the ventral pallidum mediates stress susceptibility. J Neurosci. [li nk]

Xenias H, Chen C, Kang S, Cherian S, Situ X, Shanmugasundaram B, Liu G, Scesa G, Chan CS#, Parisiadou L#. (2020). Pathogenic LRRK2 R1441C mutation is associated with striatal alterations. Commun Biol. [link] (#co-correspondence)

Cui Q, Du X, Chang IY, Pamukcu A, Lilascharoen V, Berceau BL, García D, Hong D, Chon U, Narayanan A, Kim Y, Lim BK, Chan CS. (2021). Parallel movement-suppressing striatal output pathways. J Neurosci. 41(18):3966–3987. [link]

Cui Q*, Pamukcu A*, Cherian S*, Chang IY*, Berceau BL, Xenias HS, Higgs MW, Rajamanickam S, Chen Y, Du X, Zhang Y, McMorrow H, Abecassis ZA, Boca SM, Justice NJ, Wilson CJ, Chan CS. (2021). Dissociable roles of pallidal neuron subtypes in regulating motor patterns. J Neurosci. 41(18):4036–4057. (*equal contribution) [link]

Higgs MH, Jones SA, Chan CS, Wilson CJ. (2021). Periodic unitary synaptic currents in the mouse globus pallidus during spontaneous firing in slices. J Neurophysiol. 125: 1482–1500. [link]

Pamukcu A, Cui Q, Augustine EC, Fan I, Berceau BL, Xenias H, Boca SM, Lerner TN, Chan CS. (2020). Parvalbumin+ and Npas1+ pallidal neurons have distinct circuit topology and function. J Neurosci. 40(41):7855–7876. [link]

Ganji E, Chan CS, Ward CW, Killian ML (2020). Optogenetic activation of muscle contraction in vivo. Connect Tissue Res. 62 (1), 15–23. [link]

Poulin JF, Luppi MP, Hofer C, Caronia G, Hsu PK, Chan CS, Awatramani R. (2020). PRISM: A progenitor-restricted intersectional fate mapping approach redefines forebrain lineages. Dev Cell. 53(6):740-753.e3. [link]

Abecassis ZA*, Berceau BL*, Win PH, Garcia D, Xenias HS, Cui Q, Pamukcu A, Cherian S, Hernández VM, Chon U, Kook Lim B, Kim Y, Justice NJ, Awatramani R, Hooks BM, Gerfen CR, Boca SM, Chan CS. (2020). Npas1+-Nkx2.1+ neurons are an integral part of the cortico-pallido-cortical loop. J Neurosci. 40(4):743–768. (*equal contribution) [link]

Carrillo-Reid L, Day M, Melendez AE, Xie Z, Kondapalli J, Plotkin J, Wokosin D, Chen Y, Kress GJ, Kaplitt M, Guzman JN, C. Chan CS, Surmeier DJ. (2019). Loss of TrkB receptor modulation of striatal Kv4 channels in Huntington’s disease. eLife. 8:e40818 [link]

Poulin JF, Caronia-Brown G, Hofer C, Cui Q, Helm B, Ramakrishnan C, Chan
CS, Deisseroth K, Dombeck D, Awatramani RB. (2018). Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches. Nat Neurosci. 21(9):1260–1271. [link]

David F, Carçak N, Gould T, Furdan S, Onat F, Gould T, Di Giovanni G Hernández VM, Chan CS, Lorincz M, Crunelli V. (2018). Block of hyperpolarization-activated cyclic nucleotide-gated channels of thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. J Neurosci. 38(30):6615-6627. [link]

Hunt AJ, Dasgupta R, Rajamanickam S, Jiang Z, Beierlein M, Chan CS, Justice NJ. (2018). CRF neurons synapse in the external globus pallidus to influence anxiety state. Brain Structure and Function. 223(6):2685-2698. [link]

Abrahao KP, Chancey JH, Chan CS, Lovinger DM. (2017). Ethanol-sensitive pacemaker neurons in the external globus pallidus. Neuropsychopharmacol. 42(5):1070–1081. [link]

Sebel LE, Graves SM, Chan CS, Surmeier DJ. (2017). Subchronic haloperidol induced adaptations in striatal projection neurons. Neuropsychopharmacol. 42(4):963–973. [link]

Cui Q, Pitt JE*, Pamukcu A*, Poulin JF, Kelver DA, Fiske MP, Kennedy RT, Mabrouk OS, Awatramani R, Chan CS. (2017). Astrocytic gating of striatopallidal transmission is disrupted in parkinsonian mice. Cell Reports. 17: 2431–2444. [link]

Glajch KE, Kelver DA, Hegeman DJ, Cui Q, Hernández VM, Xenias HS, Huang TY, Justice NJ, Chan CS. (2016). Npas1+ pallidal neurons target striatal projection neurons. J Neurosci. 36(20):5472–5488. [link]

Hernández VM, Hegeman DJ, Cui Q, Kelver DA, Fiske MP, Glajch KE, Huang TY, Justice NJ, Chan CS. (2015). Parvalbumin+ neurons and Npas1+ neurons are distinct neuron classes in the mouse external globus pallidus. J Neurosci. 35(34):11830–11847. [link]

Neuner S, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, Tryba KA, Greene A, Chan CS, Kaczorowski CC. (2015).TrpC3 channels critically shape spatial memory formation. Behav Brain Res. 281C:69–77. [link]

Chávez AE, Hernández VM, Rodenas-Ruano A, Chan CS, Castillo P. (2014). Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus. J Neurosci. 34(50):16621–16629. [link]

Fieblinger T, Graves SM, Sebel L, Alacer C, Plotkin JL, Gertler TS, Chan CS, Heiman M, Greengard P, Cenci MA, Surmeier DJ. (2015). Cell type-specific Plasticity of Striatal Projection Neurons in Parkinsonism and l-Dopa-induced Dyskinesia. Nat Commun. 5:5316. [link]

Plotkin JL, Day M, Peterson JD, Xie Z, Kress G, Rafalovich I, Gertler TS, Flajolet M, Greengard P, Stavarache M, Kaplitt MG, Chan CS, Surmeier DJ. (2014). Impaired TrkB signaling underlies corticostriatal dysfunction in Huntington’s disease. Neuron. 83(1):178–188. [link]

Plotkin J, Shen W, Rafalovich I, Sebel L, Day M, Chan CS, Surmeier DJ. (2013). Regulation of striatal synaptic plasticity by dendritic calcium release. J Neurophysiol. 110:2325–2336. [link]

Fan K, Baufreton J, Surmeier DJ, Chan CS, Bevan MD. (2012). Proliferation of globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons. J Neurosci. 32(40):13718–13728. [link]

Chan CS, Peterson JD, Gertler TS, Glajch KE, Quintana RE, Cui QL, Sebel LE, Plotkin J, Shen W, Heiman M, Heintz N, Greengard P, Surmeier DJ. (2012). Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice. J Neurosci. 32(27):9124–9132. [link]

Sheet PL, Suter BA, Kiritani K, Chan CS, Surmeier DJ, Shepherd GM. (2011). Corticospinal-specific HCN expression in mouse motor cortex: Ih-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control. J Neurophysiol. 106(5):2216–2231. [link]

Chan CS, Glajch KE, Gertler TS, Guzman JN, Mercer JN, Lewis AS, Goldberg AB, Shigemoto R, Fleming SM, Chetkovich DM, Osten P, Kita H. Surmeier DJ. (2011). HCN channelopathy in external globus pallidus neurons in models of Parkinson’s disease. Nat Neurosci. 14(1):86–92. [link]

Guzman JN, Sánchez-Padilla J, Chan CS, Surmeier DJ. (2009). Robust pacemaking in dopaminergic neurons. J Neurosci. 29(35):11011–11019. [link]

Deister CA, Chan CS, Surmeier DJ, Wilson CJ. (2009). SK channels regulate spike time precision through cooperative interactions with voltage-gated ion channels. J Neurosci. 29(26):8452–8461. [link]

Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier, DJ, Baram TZ, Macdonald RL, Chetkovich DM. (2009). Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. J Neurosci. 29(19):6250–65. [link]

Wu WW*, Chan CS*, Surmeier DJ, Disterhoft JF. (2008). Coupling of L-type Ca2+ channels to Kv7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity. J Neurophysiol. 100(4):1897–1908. (*equal contribution) [link]

Gertler TS, Chan CS, Surmeier DJ. (2008). Dichotomous anatomical properties of adult striatal medium spiny neurons. J Neurosci. 28(43):10814–10824. [link]

Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ. (2007). Nav1.6 sodium channels are critical to pacemaking and fast-spiking in globus pallidus neurons. J Neurosci. 27(49):13552–66. [link]

Chan CS, Guzman JN, Illijic E, Mercer JN, Rick CE, Tkatch T, Meredith GE, Surmeier DJ. (2007). ‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease. Nature. 447(7148):1081–6. [link]

Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ. (2004). D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons. J Neurosci. 24(46):10289–301. [link]

Chan CS, Shigemoto R, Mercer JN, Surmeier DJ. (2004). HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. J Neurosci. 24(44):9921–32. [link]

Wu WW, Chan CS, Disterhoft JF. (2004). The slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulation. J Neurophysiol. 92(4):2346–56. [link]

Chen L, Chan CS, Yung WH. (2004). Electrophysiological and behavioral effects of zolpidem in rat globus pallidus. Exp Neurol. 186(2):212–20. [link]

Chen L, Chan CS, Yung WH. (2002). Rotational behavior and electrophysiological effects induced by GABA(B) receptor activation in rat globus pallidus. Neuroscience. 114(2):417–725. [link]

Yung WH, Leung PS, NG SS. Zhang J, Chan CS, Chow BK. (2001). Secretin facilitates GABA transmission in the cerebellum. J Neurosci. 21(18):7063–7068. [link]

Chan PK, Chan CS, Yung WH. (1998). Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurons by cannabinoid agonist. NeuroReport. 9:671–675. [link]

Reviews & commentary

Courtney CD, Pamukcu A, Chan CS. (2023). Cell and circuit complexity of the external globus pallidus. Nat Neurosci. [link]

Hegeman DJ, Hong ES, Hernández VM, Chan CS (2016). The external globus pallidus: progress and perspectives. Eur J Neurosci. 43(10):1239–1265. [link]

Gittis AH, Berke JD, Bevan MD, Chan CS, Mallet N, Morrow MM, Schmidt R (2014). New roles for the external globus pallidus in basal ganglia circuits and behavior. J Neurosci. 34(46):15178–8. [link]

Chan CS, Surmeier DJ. (2014). Astrocytes go awry in Huntington’s disease. Nat Neurosci. 17(5):641–642. [link]

Surmeier DJ, Shen W, Day M, Gertler TS, Chan CS, Tian X, Plotkin J. (2010). The role of dopamine in modulating the structure and function of striatal circuits. Prog Brain Res. 183C:148–167. [link]

Chan CS*, Gertler TS*, Surmeier DJ. (2010). A molecular basis for the cncreased vulnerability of substantia nigra dopamine neurons in aging and Parkinson’s disease. Movement Disorders. 25(Suppl. 1):S63–S70. (*equal contribution) [link]

Chan CS*, Gertler TS*, Surmeier DJ. (2009). Calcium homeostasis in dopamine neurons and Parkinson’s disease. Trends Neursoci. 32(5):249–256. (*equal contribution) [link]

Surmeier DJ, Mercer JN, Chan CS. (2005). Autonomous pacemaker in the basal ganglia: Who needs excitatory synapses anyway? Curr Opin Neurobiol. 15(3)312–318. [link]

Chan CS, Surmeier DJ, Yung WH. (2005). Striatal information processing in globus pallidus: timing matters. NeuroSignals. 14(6): 281–9. [link]

Books & book chapters

Surmeier DJ, Shen W, Gertler TS, Chan CS. (2011). Dopaminergic modulation of glutamatergic synaptic plasticity in striatal circuits: new insights from BAC-Transgenic mice. In “Dopamine-Glutamate Interactions in the Basal Ganglia” Ed. Susan S.

Surmeier DJ, Day M, Gertler TS, Chan CS, Shen W. (2010). D1 and D2 dopamine receptor modulation of glutamatergic signaling in striatal medium spiny neurons. In: “Handbook of Basal Ganglia, 1st Edition” Ed. Steiner H, Tseng KY. p113–132.

Surmeier DJ, Day M, Gertler TS, Chan CS, Shen W. (2009). Dopaminergic modulation of striatal glutamatergic signaling in health and Parkinson’s disease. In: “Dopamine Handbook” Ed. Iversen L, Iversen S, Dunnett S and Björklund A. p349–467.